Viagra Ingredients

Viagra contains various important active as well as inactive ingredients that dictate its functionality upon consumption. Understanding what these ingredients are can help you and your doctor determine whether or not Viagra is a safe and effective option for you.

Active Ingredient: Sildenafil

The primary active ingredient in Viagra is sildenafil, which gives it the properties that allow for treatment of erectile dysfunction or sexual impotence.

 

This active ingredient of sildenafil is also used in cases dealing with heart issues, as well as pulmonary hypertension. It is marketed under the name Revatio as a blood pressure medication for both men and women. Its duality allows it to serve as both a pulmonary hypertension medication and an erectile dysfunction treatment.

How Sildenafil Works

 

Sildenafil is a cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor, which means that it prevents or inhibits PDE5 from breaking down cGMP in the body, which allows for a satisfactory penile erection upon sexual stimulation. This property is what allows for it to provide assistance to individuals struggling with erectile dysfunction.

Sildenafil is comprised of various chemicals that are synthesised through a complicated process. In order to create sildenafil, 3-propylpyrazole-5-carboxylic acid ethyl ester must be methylated (added to a methyl group) with hot dimethyl sulfate. After that, hydrolysis occurs to the above substance as aqueous sodium hydroxide is added. This degrades the substance freeing up acid.

Once there is an organic chemical compound, nitration occurs with the addition of nitric acid. Following this process, carboxamide is formed with refluxing thionyl chloride. The nitro group formed earlier is reduced to an amino group, and 2-ethoxybenzoyl chloride is subject to acylation, meaning that an acyl group is added to a compound.

The compound is then subject to cyclisation followed by sulfonation to chlorosulfonyl, and condensed with 1-methylpiperazine. This process culminates in sildenafil citrate.

Dosing

Viagra comes in doses of twenty-five milligrams, fifty milligrams, and one hundred milligrams in pill form. Its packages each contain four tablets of Viagra. The packages are small due to the fact that only one pill of Viagra should be taken per day. It is best taken on an empty stomach with a full glass of water.

Inactive Ingredients

Besides its complex and monumental active ingredient sildenafil, Viagra also includes several helpful inactive ingredients that serve a number of purposes important to the functionality of the drug. These inactive ingredients include microcrystalline cellulose, croscarmellose sodium, anhydrous dibasic calcium phosphate, magnesium stearate, titanium dioxide, hypromellose, lactose, triacetin, and FD & C Blue #2 aluminium lake.

Microcrystalline cellulose is used commonly as a texturiser and an emulsifier, which is useful for the pill form of Viagra. Calcium phosphate in the pharmaceutical industry is used as a diluent, which is, as a substance to dilute another substance. Being anhydrous and dibasic indicates that water has been removed from this calcium phosphate, and the calcium phosphate contains two replaceable hydrogen atoms.

The drug also contains croscarmellose sodium, which is used as a superdisintegrant and an emulsifier alongside microcrystalling cellulose. Because it is cross-linked, which promotes a difference in the polymers physical properties, the croscarmellose sodium is able to absorb water with decreased water solubility. This is the property most effective in Viagra, as it allows the pill to be dissolved more quickly into the body, making Viagra more effective long-term than other erectile dysfunction drugs that do not include croscarmellose sodium.

Pharmaceutical companies commonly use magnesium stearate as a lubricant during the manufacturing process of pills and tablets. It is an anti-adherent, which prevents the components of a pill, tablet, or powder from sticking to tools and equipment during the manufacturing process. Due to the fact that it may also slow the tablet disintegration once consumed, it is paired with croscarmellose sodium, which will cancel out these effects.

Hypromellose is the short name for hydroxypropyl methylcellulose. It has a very important function in the Viagra medication, and that function is controlled-release. This allows for the effects of the tablet to be delayed until the pill reaches the digestive tract, making its effects stronger and longer lasting. Titanium dioxide is pigment. Lactose is used in pills often for its mild flavour, allowing the tablet to dilute the stale taste of the other ingredients, making it more pleasant to swallow.

Finally, triacetin is an acetylating agent, which as stated before, is an important part of the synthesis of sildenafil, and FD & C Blue #2 aluminium lake is used to create the signature blue hue of Viagra.